Example One: (nuisance)
Change the blipmode to 1. Blipmode leaves a tiny "X" everywhere the user clicks for no good reason. Well I think the reason was in the old days we wanted feedback to where we just clicked.
Example Two: (annoying)
Set zoomfactor to 5. This slows your scroll wheel down to about old-lady.
Example Three: (irritating)
Type in vtoptions and set the Transition speed all the way to slow. This will make a zoom all take about all of a guys lunch break.
Example Four: (offensive)
Change mbuttonpan to 1. this will bring up object snaps instead of letting you pan with the mouse.
Example Five: (painful)
Change pickadd to zero. This makes it so you can only pick one element at a time.
Example Six: (jerk)
Change highlight to zero. This turns off the highlighting of selected objects.
Example Seven: (extreme jerk)
Use aliasedit to change common keyins like E for the line command.